Coastal Highway has milder weather than either Mountain Town or Mystery Lake and plentiful looting opportunities, but parts of the map, especially near the Quonset Garage, tend to have a high population of dangerous animals.Mystery Lake has a moderate number of structures and low predator density, along with lots of hunting opportunities, and is a good choice for new players.It also doesn't have any fishing, eliminating one potential food source.
For new players, it's likely best to start in one of the four regions below.
When you start a new game of The Long Dark in any difficulty other than Interloper, you will be given a choice of regions you can start in, which will greatly affect the initial difficulty of the survival experience.